Reductive coupling of terpenic allylic halides catalyzed by Cp2TiCl: a short and efficient asymmetric synthesis of onocerane triterpenes.
نویسندگان
چکیده
[reaction: see text] Titanocene chloride catalyzes the regioselective alpha,alpha'-homocoupling of terpenic allylic halides. This process has been employed in the short and effective synthesis of terpenoids such as beta-onoceradiene (1), beta-onocerin (2), and squalene (3). Evidence is presented for eta1-allyltitanium species being involved in the coupling.
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ورودعنوان ژورنال:
- Organic letters
دوره 7 12 شماره
صفحات -
تاریخ انتشار 2005